Predictors

ASCs are experienced differently by different individuals, and several factors act as predictors that profoundly influence both the depth and quality of these experiences.

Modern research is uncovering how individual differences—from genetics and brain structure to prior trauma and psychological openness—can shape responses to psychedelics and other ASC-inducing methods.

• Absorption: Strongest predictor; immersion trait linked to ASC depth.

• Openness: Associated with frequency/intensity; psychedelics increase trait long-term.

• Cognitive flexibility: Both baseline and ASC-induced flexibility.

• Expectancies: Mindset, intention, and belief shape experiences.

• Suggestibility: High in hypnotic, placebo, guided modalities.

• Neurobiology: 5-HT2A receptor density, DMN connectivity, brain entropy, genetic factors.

• Demographics: Age, gender, cultural background modulate experience.

• Clinical screening: Advanced protocols for safe application in therapy.