# Predictors

Modern research is uncovering how **individual differences**—from genetics and brain structure to prior trauma and psychological openness—can shape responses to psychedelics and other ASC-inducing methods.

* **Absorption:** Strongest predictor; immersion trait linked to ASC depth.
* **Openness:** Associated with frequency/intensity; psychedelics increase trait long-term.
* **Cognitive flexibility:** Both baseline and ASC-induced flexibility.
* **Expectancies:** Mindset, intention, and belief shape experiences.
* **Suggestibility:** High in hypnotic, placebo, guided modalities.
* **Neurobiology:** 5-HT2A receptor density, DMN connectivity, brain entropy, genetic factors.
* **Demographics:** Age, gender, cultural background modulate experience.
* **Clinical screening:** Advanced protocols for safe application in therapy.